Can Luteolin Improve Testosterone? A Look At Scientific Research

Luteolin testosterone

Luteolin – will it boost your testosterone?

That’s a great question.

Before answering that, we thought you first might want to know what Luteolin exactly is.

For starters, it’s a flavonoid and antioxidant. You’ll find it in fruits, vegetables, and herbs for the most part.

Experts have discovered that it’s able to inhibit the aromatase enzyme, which is responsible for turning testosterone into estrogen (female hormone).

This captured my attention and I decided to look further into research. I did the digging and found some surprising info.

And I’ve decided to share it with you today.

In this article, we’ll be talking about Luteolin’s effects on testosterone, its key benefits, safety profile, and more.

Everything you find here is backed by scientific research.

No BS. No bro-science.

What Exactly Is Luteolin?

Luteolin is a flavonoid and antioxidant. Scientifically called 3′, 4′, 5, 7-Tetrahydroxyflavone, it naturally occurs in nature.

A tree called Terminalia Chebula contains plentiful amounts of Luteolin – mainly in the bark and leaves.

However, you don’t need to go chop trees in the woods to obtain this flavonoid.

You can also find it in fruits, vegetables, and herbs. These include broccoli, leafy greens, green pepper, carrots, parsley, oregano, and many more.

Chinese people first stumbled upon some of the benefits associated with Luteolin. They discovered that it could possess potent aromatase inhibitor properties. [2]

In other words, they discovered that it can block aromatase, an enzyme that converts testosterone into estrogen (female hormone). [3]

While the science is still new, ingredients like Luteolin are thought to boost testosterone levels indirectly by decreasing estrogen sex hormone.

Interesting Fact: Luteolin was discovered in the late 1930s by the biochemist called Albert Szent-Györgyi. He discovered that Luteolin is a part of flavonoid group and initially named it vitamin P. However, this was later changed because flavonoids, while beneficial, aren’t as essential for our health as vitamins are. [1]

A Potent Estrogen Blocker?

Due to its benefits, Luteolin is a part of some testosterone boosters. However, it’s not nearly as popular as DIM, which is another aromatase inhibitor.

That’s a shame, because new research suggests that Luteolin might have even more powerful effects for regulating estrogen in males than DIM.

That’s one of the reasons why I created this article. To shine the awareness on this ingredient and review all of its effects on testosterone.

Shall we continue?

How Does It Affect Your Testosterone?

As I previously said, Luteolin is an aromatase inhibitor.

As such, it helps prevent the aromatase enzyme from doing its thing – which is converting testosterone to estrogen. [3]

While estrogen is a female hormone, males too have a certain amount in their system. However, too much estrogen in a man’s body can cause a whole host of health problems.

From minor issues such as man boobs and belly fat, to bigger problems such as hormonal changes, male menopause (a situation where man’s androgen hormones drop low and he experiences a flood of female hormones – not good), mood changes, and so on.

Luteolin Is A Nightmare For The Aromatase Enzyme

Obviously, a high amount of testosterone and low levels of estrogen is the ideal scenario if you’re a male.

And Luteolin seems to help with that.

By blocking the aromatase enzyme, it prevents your testosterone from converting to estrogen. Allowing you to have more available testosterone circulating through your body. [3, 4]

This means that Luteolin is an indirect testosterone booster. While it might not directly raise your testosterone, it can be a great addition to T-boosting stacks.

It cleans out the estrogenic mess to allow the other T-boosting ingredients do their job. Which is to raise the male hormone.

If you’re curious about which ingredients go well with Luteolin, keep reading. I’ll cover that in a second.

What Do Other Studies Say

Interestingly, there are some conflicting cases in regards to Luteolin’s effects on aromatase.

One study has found that this flavonoid doesn’t actually affect aromatase directly.

Instead, it blocks other enzymes that are involved in the synthesis of aromatase. These enzymes include phosphodiesterase type 4 and adenosine monophosphate.

By blocking these enzymes, Luteolin indirectly inhibits the synthesis of aromatase – that’s what the study concluded. [5]

So either way, it appears that Luteolin indeed inhibits the production of the aromatase enzyme. Whether that’s directly or indirectly.


The studies on Luteolin are fairly limited. Still though, current research looks promising. It appears that this flavonoid increases testosterone indirectly by blocking the aromatase enzyme. Aromatase is responsible for converting testosterone to estrogen (the female sex hormone). By blocking this process, Luteolin helps maintain higher testosterone levels in your body.

Sources of Luteolin

At the beginning of the article, I briefly mentioned some food groups that contain Luteolin. Now I’ll list you exactly which foods are the richest source of this flavonoid.

Starting with vegetables:

  • Raddichio
  • Green Peppers
  • Celery
  • Chicory Greens
  • Hot Chilli Peppers
  • Pumpkin
  • Lettuce
  • Artichokes
  • Spinach
  • Broccoli

Best fruit sources:

  • Lemon
  • Cantaloupe
  • Kiwi
  • Navel Orange
  • Watermelon
  • Red Grapefruit

Again, you can also find Luteolin in testosterone boosting supplements. There, it’s often included alongside other T-boosters to synergize their effects.

However, if for any reason you’d like to supplement it separately, you can do that too. It’s available in supplement forms, such as capsules and tablets.

Other Core Benefits

Fights Off Cancer Cells

Luteolin disturbs almost all types of malign cells in the body. [6]

It prevents the growth of new vassal tissue in tumors. It also slows down the metabolism of cancer, along with suppressing recycling or tumor cells.

Most important of all, it appears to induce cancer cell death.

Mice studies show how it slows down the growth of various types of tumors. Including hepatoma, skin carcinoma, and ovarian cells cancer.

It also reduced the chance of developing tumors, as well as decreasing the size of tumors in sick mice. [6]

What’s more, there were no side effects to taking Luteolin long term. Nor there was any toxicity. Even at high doses at 30mg/kg. This proves its safety as an anti-cancer compound.

Additionally, in vitro studies show how it has both preventative and therapeutic effects against estrogen-related cancer. [6]

Protects You Against The Damaging Sun Rays

Luteolin appears to effectively reduce skin damage as a result of UVB radiation exposure.

What’s more, it helps to prevent wrinkle formation and skin aging, as shown in studies. [7]

Reduces Oxidative Stress

As an antioxidant and flavonoid, Luteolin inhibits oxygen species in the body. These oxygen species cause damage in our cells and DNA.

So by preventing their mechanisms, it helps strengthen antioxidant defense in the body and reduce cell damage. [12]

Reduces Inflammation In The Body

Animal experiments suggest that Luteolin suppresses inflammation induced by various forms of bacteria. [6]

It also inhibits two key pathways which send signals to the body to induce inflammation. This results in reduced chronic, and acute inflammation.

Furthermore, Luteolin was able to inhibit both cytokine and pro-inflammatory marker expressions. Leading to the same result – reduced inflammation.

In one experiment, researches caused toxin-induced uveitis in rats, after which they treated them with Luteolin. The results showed significantly reduced inflammation. In fact, the effects were comparable to prednisolone, a steroid medication. [8]

Among all of this, Luteolin can also suppress inflammation in the colon. [9]

Supports A Healthy Heart

Studies suggest that Luteolin helps prevent the death of healthy heart cells. This can be extremely beneficial for people who want to prevent or treat a cardiovascular disease. [10]

It also helps increase cell life. The way it does this is by reducing oxidative stress in the cells themselves, prolonging their life. This makes total sense considering that Luteolin is an antioxidant. [11]

Better yet, Luteolin appears to improve and speed up the recovery of healthy cells. It also improves blood flow by reducing oxidative stress in healthy blood cells. [10]

How You Can Boost Luteolin’s Effects on Testosterone

The number one way you can boost Luteolin’s efficacy is by pairing it with another testosterone booster.

Here are some of the best natural T-boosting ingredients available:

Ashwagandha – An Ayurvedic herb that’s famous for its ability to reduce cortisol. As you may know, cortisol is damaging to testosterone. By preventing this, Ashwagandha helps your body retain more of the male hormone. Studies suggest that it also boosts testosterone directly, in addition to reducing cortisol.

Boron – A mineral which at doses over 10mg daily causes a spike in testosterone levels in males. It also helps support prostate and bone health.

D-Aspartic Acid – If you suffer from low testosterone, then D-Aspartic Acid might be perfect for you. Studies show it helps greatly increase T levels in inactive people, as well as those who suffer from low levels of the male hormone. It doesn’t seem to work in athletes and resistance-trained men though.

Fenugreek – If you have inflammation in the body, this can wreak havoc on your hormones. Fenugreek helps with this because it suppresses inflammation, thus indirectly boosting testosterone. What’s more, Fenugreek also boosts testosterone directly in addition to its anti-inflammatory effects.

Korean Red Ginseng – It helps reduce high blood sugar, which is one of the culprits of low testosterone. Animal studies show that Korean red ginseng boosts testosterone directly, too.

Vitamin D – Vitamin D plays a key role in testosterone synthesis in the body. In fact, if your vitamin D levels are low, chances are your testosterone is too. So better go get in the sun – or take Vitamin D in a supplement!

Oyster Extract – Rich in nutrients and vitamins, including zinc. Zinc is very important for testosterone regulation. Also, low levels of zinc lead to weak testosterone and poor immune system.

Dosage Guide

Okay, so here’s the thing.

Research on Luteolin is scarce and its hard to find the exact optimal dosage. In fact, at the time of writing this article, the official suggested dosage still hasn’t been established.

However, most products with Luteolin dose it between 50 and 75mg. 60mg seems to be the golden number.

None of the users of these products reported side effects. They also said they experienced its benefits when taking these products.

As a result, I’d recommend shooting for around 60mg of Luteolin in a supplement. That appears to be a safe and also effective daily dose.

Safety Profile

From the available research, Luteolin appears to be reliable and safe compound.

There are no reported side effects from people, but also in animals who were tested in studies.

I always like to say: If you have any concerns, talk to your doctor first. This way you’ll know whether it’s a good idea to take a supplement or not.

But again, as long as you shoot for the safe dosage, such as the one I showed above, you’ll be good.


When looking to improve your testosterone, the solution isn’t always to try to increase it directly.

Sometimes, it’s about getting rid of problems that block you from producing testosterone naturally.

Aromatase is one such problem. It’s an enzyme which turns your testosterone into estrogen. To reduce its amount in your body, it’d be a good idea to take an aromatase blocker such as Luteolin.

By regulating estrogen production, you effectively allow for more testosterone to flow through your veins.

Add natural testosterone boosters on top of that, and you’ll be making some serious T gains.


[showhide type=”links” more_text=”Show References” less_text=”Hide References”]

[1] Luteolin – Science Direct Article.

[2] Traditional Chinese Medicine: In-Depth – NCBI article.

[3] Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19).

[4] Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes.

[5] Whitening activity of luteolin related to the inhibition of cAMP pathway in alpha-MSH-stimulated B16 melanoma cells.

[6] Luteolin, a flavonoid with potentials for cancer prevention and therapy.

[7] Luteolin suppresses UVB-induced photoageing by targeting JNK1 and p90RSK2.

[8] Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats.

[9] The Flavonoid Luteolin Worsens Chemical-Induced Colitis in NF-κBEGFPTransgenic Mice through Blockade of NF-κB-Dependent Protective Molecules.

[10] Antioxidative effect of luteolin pretreatment on simulated ischemia/reperfusion injury in cardiomyocyte and perfused rat heart.

[11] ERK/PP1a/PLB/SERCA2a and JNK Pathways Are Involved in Luteolin-Mediated Protection of Rat Hearts and Cardiomyocytes following Ischemia/Reperfusion.

[12] Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype.


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