Bioperine is a patented type of pepper extract found in black pepper fruit.
It comes from the standard black pepper, called Piper Nigrum L. Or from the long pepper, also known as Piper Longum L.
Bioperine is made up of 95% piperine, which is the key compound of black pepper.
The majority of benefits that you experience from consuming black pepper come from piperine. In fact, Bioperine and piperine are pretty much the same things.
One of the most interesting benefits of Bioperine is that it can improve absorption of other nutrients, i.e. increase bioavailability in your body.
It’s often paired with testosterone boosting ingredients to improve their effects on the male hormone.
Bioperine’s amazing properties and safety profile have even been studied and proven by the US clinical trials.
That said, let’s dive deep into the science and discover everything Bioperine has to offer.
Where Does Bioperine Come From?
Piperine originally comes from Southern India. This is where black pepper fruit grows and is harvested by people once the berries get ripe.
Once the berries are harvested, they are then dried on the sun to improve their quality.
The black pepper extract comes from these very berries. Its name is piperine. Studies suggest it’s so beneficial for the human body that the US science facilities patented it under the name Bioperine as we know it.
Usually, black pepper contains about 9% piperine. However, Bioperine is almost entirely made up of piperine – containing an incredible 95% of the extract. This ensures maximum benefits of the compound.
What is it Used For?
Bioperine is used in many supplements. Especially testosterone boosters.
This is due to its amazing properties of enhancing other ingredients. See, Bioperine doesn’t do much on its own. However, when combined with other nutrients, it can greatly improve their efficiency. 
And how does it do it?
Simply put, piperine, the active component of Bioperine, prevents enzymes in the body from attacking other molecules.
So when you take Bioperine with, let’s say, ashwagandha extract, it improves the benefits of the herb. Some of the ashwagandha’s benefits include stress reduction, testosterone increase, and cognitive boost.
Bioperine also speeds up your metabolism and improves digestion, which translates to better nutrient absorption. 
Piperine compounds in Bioperine allow for nutrients to flow through your body much quicker, ensuring efficient delivery.
Nutrients That Synergize Well With Bioperine
There are certain nutrients that synergize better with Bioperine than others.
We did the research to find all the nutrients that benefit from Bioperine the most.
Let’s have a look:
- Vitamins and Minerals – Vitamin A, Vitamin B6, Vitamin B12, Vitamin C, Vitamin D, zinc, and magnesium
- Amino Acids – isoleucine, threonine, tryptophan, and D-Aspartic Acid (t-booster)
- Antioxidants – Vitamin E, beta-carotene, lutein, selenium, and pine bark bioflavonoids
- Natural Herbs and Extracts – Curcumin, Ashwagandha, Fenugreek, Stinging Nettle, and others.
Bioperine’s Effects on Testosterone
As I’ve already said, piperine in and of itself doesn’t have any direct impact on testosterone. At least not according to the current studies.
So while it may not have a direct impact on your male hormone, piperine will definitely ramp up your T by boosting other ingredients.
When looking for a T-boosting supplement, make sure it contains Bioperine (piperine) in it. It would be a waste not to take advantage of the amazing benefits this ingredient can offer.
Other Core Benefits of Bioperine
Helps You Lose Fat
Earlier I mentioned how piperine speeds up your metabolism and thus helps with nutrients absorption.
You might wonder how exactly does it do it.
The process behind is relatively simple. Piperine, Bioperine, or however you want to call it (it’s the same thing after all), is a thermogenic ingredient. Meaning it makes your body burn more calories.
So basically, this process enables your body to store less, and burn more fat. Bioperine makes your metabolism work harder, leading to a breakdown of fat cells in your body. Which ultimately helps you regulate your weight. 
It’s worth mentioning that these effects aren’t huge. Bioperine alone won’t likely help you burn 20 lbs of fat.
However, pair it with other fat burning ingredients, and you have a potent combo for weight loss.
Strengthens Your Immune System
If you suffer from problems with the immune system, Bioperine a.k.a piperine can help. It helps regulate your body’s defenses, so that when they’re overly active, it weakens their response.
On the same token, when your immune system ‘falls asleep,’ Bioperine essentially helps it to come back to life – stimulating your lymphocytes.
Overall, this can help you tame inflammation in the body and get your immune system back under control. 
Helps Improve Mood
Studies link Bioperine to an increase in dopamine and serotonin levels in the brain. 
As you may or may not know, dopamine is our reward and pleasure neurotransmitter. It’s often called the ‘feel-good chemical.’ And for a good reason. It keeps you motivated, energized, and focused on the task ahead. 
Know that feeling when you bite into a cheesy, juicy slice of pizza? That’s dopamine. My apologies if you don’t like pizza.
And what about serotonin? Well, serotonin is another neurotransmitter that also influences how we feel. Besides regulating mood, serotonin controls our appetite, body temperature, and even sleep. 
During the day, when your eyes are under exposure to the sun, your brain produces serotonin. When the sunlight begins to fade, your brain then converts the serotonin that was produced during the day into melatonin – the hormone responsible for getting you to sleep.
What has any of this to do with black pepper? Well, since black pepper helps stimulate serotonin and dopamine production, it can lead to a number of benefits. Such as:
- Improved mood
- Healthy appetite
- Better sleep
Boosts Cognitive Function in Your Brain
There are studies which suggest that Bioperine can help boost cognitive functions in the brain. This includes attention, focus, and motivation.
Simply put, that black pepper you use for spicing up your food might help improve your overall productivity and sharpen your cognitive abilities.
If you feel like you need an extra kick of motivation, Bioperine can help. It’s also shown to help manage stress levels, which can indirectly help with productivity, motivation, and other mental abilities. 
Alongside boosting general cognitive functions, piperine also helps improve memory. As I mentioned earlier, piperine improves the communication of certain neurotransmitters. Such as dopamine, beta-endorphin, and serotonin. 
These neurotransmitters all play an important role in how our memories are formed. With an optimal ratio of these neurotransmitters in your brain, you’ll be sure to have an improved memory. This becomes increasingly important as we get older.
Aids Your Digestive System
Piperine in black pepper has antidiarrheal properties. Meaning it helps prevent diarrhea, constipation, stomach pains, and other gastrointestinal problems. It can even help treat IBS (irritable bowel syndrome). 
A recent study researched the link between IBS, depression, and piperine. They gave piperine extracts to animals who had IBS. Within a short space of time, the test subjects showed a significant improvement in their mood, as well as serotonin regulation in their colons. 
And how does this relate to IBS? Well, evidence shows that irregularities in serotonin production and brain-gut communication all play an influence on IBS .
Lowers Cholesterol and Blood Pressure
Among its health benefits, black pepper extract has a lipid-lowering effect. A study in rats showed how adding piperine to their diet reduced their cholesterol levels and triglycerides. 
But piperine doesn’t reduce all cholesterol. In fact, it specifically targets bad cholesterol, LDL, and reduces its values in the blood. On the other hand, it also helps to elevate the levels of HDL, which is good cholesterol. 
This is just one of the studies showing the possible benefits of piperine on cholesterol and triglycerides.
Another benefit related to this is an improvement in cardiovascular health. One animal study showed how piperine was able to reduce blood pressure in study subjects. 
For the purpose of enhancing other ingredients and their bioavailability, take 20mg of bioactive piperine. In this case, Bioperine.
If you don’t have a Bioperine supplement, don’t worry! Head down to the nearest grocery store and buy regular black pepper powder – it will provide you with the same benefits.
The optimal dosage for black pepper powder is between 500-1500mg for the purpose of enhancing other supplements.
You can easily achieve this dose by sprinkling your meals with it. You can also put it in an empty capsule if the taste is too much for you. Or any other method you might prefer.
In the optimal dosages, piperine aka Bioperine is perfectly safe to take. It’s clinically tested for efficacy and safety.
Just make sure to read the instructions when taking a Bioperine supplement. Never exceed the recommended dosage that’s written on the bottle.
The same thing goes for black pepper. The safe upper limit for black pepper is around 15 grams, which is really a lot. Even if you’re a spicy food fanatic like me, you won’t be able to get even near that number.
Still, if you somehow manage to take more than 15g, then it can become dangerous. Extremely high doses of black pepper are shown to cause liver failure.
Bioperine, also called piperine, is a patented extract of black pepper. It grows in Southeast India and is harvested from black pepper fruit (berries).
By itself, Bioperine doesn’t offer too many huge benefits. Taken alone, it can’t boost testosterone directly.
However, when you pair it with other ingredients, that’s where Bioperine shines. It improves the effects of other T-boosting nutrients, indirectly increasing your testosterone levels.
Furthermore, Bioperine does, in fact, offer some slight benefits of its own. These include:
- Improved digestion
- Enhanced mood
- Boosts cognitive function
- Helps lower bad cholesterol and blood pressure
The optimal dose for Bioperine is around 20 milligrams. This dosage is perfect for increasing the bioavailability of other ingredients, along with offering you some of its own benefits.
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 Bioavailability enhancers of herbal origin: An overview.
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 Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures.
 Indian Spices for Healthy Heart – An Overview.
 Inhibition of lipopolysaccharide-induced inflammatory responses by piperine.
 Antidepressant-like effects of piperine and its derivative, antiepilepsirine.
 Psychologytoday.com article on dopamine.
 Psychologytoday.com – Serotonin: What It is and Why It’s Important for Weight Loss.
 Piperine, the potential functional food for mood and cognitive disorders.
 Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders.
 Effect of piperine on 5-HT and synaptophysin expression of rats with irritable bowel syndrome.
 The role of serotonin in irritable bowel syndrome: implications for management.
 Vijayakumar RS, Surya D, Senthilkumar R, Nalini N. Hypolipidemic effect of black pepper (Piper nigrum Linn.) in rats fed a high-fat diet. J Clin Biochem Nutr. 2002;32:31–42.
 Blood pressure lowering and vasomodulator effects of piperine.