Top 15 Most Effective Natural Nootropics Reviewed

Here you’ll find everything you need to discover what makes your brain function to its best abilities using natural, and the most effective nootropics.

If you’re looking to boost through work plateaus, prevent age related cognitive decline or come up with the next amazing idea to become the new 21st century Einstein then natural nootropics will get you there.

“The understanding of the mechanism stimulated by nootropic is expected to increase the cognitive performances of the cognitive impairment patients.”

These smart drugs are being tested extensively every year, and all the results are coming back positive.

From the Silicon Valley professionals to university student and retired people are all seeing amazing benefits using natural nootropics.

What can you experience when using natural nootropics?

  • Quicker thinking
  • Ability to hold more information
  • Better sports performance
  • Reduced ADHD
  • More energy
  • Increased creativity
  • Improved mental health for the ageing population

Needless to say, there are hundreds, if not thousands of benefits you can experience from using a natural nootropic.

Here, we’ll uncover everything you need to know about how these amazing smart drugs work.

Most Effective Nootropics

What To Look out For in Natural Nootropics

Follow our step-by-step guide to learn how to get the most from a natural nootropics, including a detailed analysis of the best nootropic on the available today.


Let’s look closely at what ingredients work, and which do not when it comes to getting the most out of your brain power.

There are many reputable companies out there who offer quality natural nootropics. Such as MindLabPro, where all of their ingredients have been carefully tested and out under the microscope by professional scientists.

On the other hand, there are other companies who offer the opposite – Nootropics that contain cheap imitations or unnatural ingredients that have been banned by many countries.

Here, we’ll look closely at the main ingredients contained in natural nootropic. Let’s look at how you can choose the best natural nootropics available today.

Best natural ingredients

Here we’ve listed the best natural nootropc ingredients that are safe, and have been proven to work with the body to improve its capacity to enhance the ind, and its ability to perform at its peak.

Most of these ingredients can be found naturally in foods. This is why we highly recommend choosing the natural path, as this will always be the best option for long term health and lasting results.

#1 Citicoline

Citicoline helps energize brain cells while optimizing the neural electrical impulses that power all neurons thought the brain. Studies show that using CDP-choline supplements may increase dopamine receptor densities.

Along with the prevention of memory impairment, resulting from poor environmental conditions. Extensive research has shown that citicoline supplements help improve focus and mental energy. See the study here –

#2 Phosphatidylserine

PS is a phospholipid compound that comprises 15% of the brain’s fats. (High doses can be found in soy lecithin) It’s concentrated in brain cell membranes, where it helps improve fluidity, optimize brain cell receptors, and promotes neurotransmitters like acetylcholine and dopamine the feel good chemicals.

#3 Vitamina B6

B6 optimizes neurotransmitters, helping synthesize serotonin, norepinephrine and GABA while supporting Tryptophan → serotonin, 5-HTP → serotonin, and DOPA → dopamine conversions.

All of which are important for improving mood and brain cell responses. B6 can be found in pork, poultry, and soy. It also helps to improve the digestion of food, and nutrients into the body.

#4 Vitamin B12

B12 is an important essential nutrient for the central nervous system that runs throughout the entire body, including the brain. Where it stimulates the formation of healthy, protective nerve cells.

B12 is a necessary nutritional component in peak brain energy metabolism and production of brain chemicals. B12 can be found naturally in liver, fish, red meat and eggs.

#5 Rhodiola rosea

Rhodiola is said to stimulate and sustain cognition-critical neurotransmitters including norepinephrine, dopamine, and serotonin – simply put, it helps you to think quicker.

It may further optimize these neurotransmitters by helping their transport across the blood-brain barrier. Rhodiola rosea can be found in wild Arctic regions of Europe, including Britain, Asia, and North America.

#6 L-Theanine

L-Theanine helps to increase the activity of alpha brainwaves, which are associated with a state of wakeful relaxation and enhanced creativity, much like an adaptogen.

It appears to calm ”excitable” neurotransmitters while promoting ”relaxing” neurotransmitters like serotonin, dopamine and GABA. L-Theanine can be found in bananas, green tea, nuts, beef liver, brown rice to name a few.

#7 Tyrosine

Tyrosine is an amino acid compound used to synthesize catecholamine neurotransmitters involved in memory, mood and mental processing.

This includes dopamine, epinephrine, and norepinephrine. Research suggests that tyrosine may counter the impact of brain stress, restoring neurotransmitters that are depleted by stress to promote peak cognitive function.

Tyrosine can be found in cheese, soybeans, beef, lamb, pork, fish, chicken, nuts, seeds, eggs, dairy and whole grains.

#8 Pterostilbene

A high-bioavailability polyphenol, pterostilbene has soothing antioxidant properties that help maintain healthy brain function during the aging process.

For years doctors have said dark chocolate is good for the body, and mind, this is because pterostilbene can be found in blueberries, almonds, mulberries, peanuts, red wine, red grapes, and cocoa to name a few.

#9 Lion’s Mane Mushroom

Hericium erinaceus is the only mushroom that supports brain health. Lion’s Mane supplies active nootropics called hericenones and erinacines through the brain receptors. Research suggests Lion’s Mane stimulates Nerve Growth Factor (NGF) production.

This accelerates neural regeneration and myelin improves nerve sheath synthesis. (Myelin is a fatty white substance that covers the axon of some nerve brain cells, forming an electrically insulating protective layer. It is essential for the correct functioning of the nervous system.)

Optimized NGF could also support brain plasticity to enable new learning and the capacity to hold new information. Along with promoting healthy brain cell replication, and a strong brain cell membrane function.

Hericium erinaceus is an edible and medicinal mushroom belonging to the tooth fungus group. Native to North America, Europe and Asia it can be identified by its long spines, and its appearance on hardwood trees.

Un-natural and banned ingredients to avoid

In this section, we’ll look at the most popular, non-natural nootropics and also stimulants that have been widely tested on their benefits, and in some cases, their side effects.

As some of these compounds fall under the category of stimulants, we advise caution if considering the use of banned substance that cause over stimulation. `

Simulants over-excite the mind, and nervous system. We feel stimulants should not fall under the same radar as nootropics, as this defeats to purpose of enhancing the brain’s capacity naturally – as the natural path is always the best option for long term health.

With all said and done, let’s look at the worst ingredients for nootropics:

#1 Modafinil

Modafinil has been used for treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea.

It has also seen widespread off-label use as a purported cognition-enhancing agent. However, it has now been shown that Modafinil now appears to be relatively weak, and typical dopamine reuptake inhibitor.

It’s also worth knowing that Modafinil is classified as a schedule IV controlled substance and restricted in availability and usage in the UNited States. This is due to concerns about possible addiction potential.

In most other countries around the word, it is a prescription drug, and not otherwise legally restricted. Countries like Egypt, it is easily obtained over the counter.

#2 Adrafinil

Adrafinil is a discontinued wakefulness-promoting agent that was used in France to promote alertness, attention, wakefulness, mood enhancement, and other positives, particularly in the elderly.

It was also been used by people who wished to avoid fatigue, such as night workers or others who needed to stay awake, and alert for long periods of time. Adrafinil is also widely known as a nootropic agent.

In some cases, Adrafinil may cause diarrhea, headache, nausea,vomiting, a loss of appetite, irritability, nervousness, insomnia, and a dry mouth to name a few.

#3 Aniracetam

Aniracetam, also known as N-anisoyl-2-pyrrolidinone, is an ampakine compound of the racetam chemical class. It is sold throughout Europe as a prescription drug, but it is not approved by the Food and Drug Administration in the United States.

Aniracetam has been shown to positively modulate the AMPA receptor. However many reported side effects are insomnia, headaches, anxiety, pain, vertigo, and nausea.

#4 Noopept

N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111, brand name Noopept is sold as a nootropic.

It was first synthesized in Russian in 1996, and is orally available since then. As of 2017, its metabolism were not well known, as  its effects had not been measured in humans following administered dosage. Large studies are yet to be carried out on this substance.

#5 Pramiracetam

Pramiracetam is a central nervous system stimulant and nootropic agent belonging to the racetam family of drugs. It sold for the treatment of memory and attention deficits in aging people with neurodegenerative and vascular dementias in Italy, and some Eastern European countries.

Cambridge Neuroscience, Inc (CNI) had permission from the FDA in 1991 to conduct Electroconvulsive therapy (ECT) testing Pramiracetam. However, this was later withdrawn when CNI abandoned the drug.

1.1. Summary of ingredients:

Looking through the list of natural and safe nootropic ingredients, and the not so safe non-natural ingredients, it’s clear to see there’s been extensive research done in testing the possibilities when it comes to the benefits of nootropics.

We always recommend choosing the natural and safe route. As this has proved beneficial for long term health and vitality, as opposed to aggressive tactics form singular chemically derived stimulants and nootropics.

2.Who can benefit from using nootropics

As you can see from the benefits natural nootropics has to offer listed in the ingredients section, everyone can benefit from using a natural nootropic.

There’s no limit to what a smart drug can do to optimise your life, as they work to improve your memory, and processing capabilities.

If you’re a school teacher, student, creative person, or perhaps you suffer from age related cognitive decline, you could receive benefits by using a quality natural Nootrópico

(image courtesy of MindLabPro – showing the improvement in brain function through Citicoline)

2.1 Age related population | cognitive decline

Laboratory studies (in age-related diseases) shows that a reduction in the neurotransmitter acetylcholine (ACh) contribute to memory loss.

However, after supplementing with Citicoline – the chemical directly linked to improving neural electrical impulses throughout the brain, improve the ACh levels.

Low levels of ACh have been linked to neurological and learning problems. Thus, anyone who suffers from cognitive decline would benefit by using a natural nootropic that supports the re-growth of ACh.

Nootropics helps to improve the capacity to think, to  learn, and to perform challenging tasks due to their ability to promote memory and learning.

2.2 Athletes

Natural nootropics aren’t only for the aging population, or students wishing to excel at their studies – they’re also beneficial for athletes.

Using a natural nootropic for sports and performance could benefit you by increasing your mental focus, which in turn, will promote the ability to push through plateaus, or boundaries.

If you are taking part in resistance training, or endurance events, using natural nootropics could give you that added edge you need over your competition.

2.3 Work Professionals

In this category (Professionals) we refer to anyone and everyone, that takes part in any work activity that involves the need to process new information and ‘think.’

As we all work to improve our lives, both personal and at work, using natural nootropics will benefit those who need to improve their memory, boost their mood, and work for long periods of time with less effort.

This could be athletes, skilled labourer, students, lawyers, doctors and nurses or creative professional. Those deciding to use natural nootropics, can experience numerous health benefits.

  • Creatives
  • Athletes
  • Aging individuals
  • Students
  • Business professional
  • Entrepreneurs
  • Skilled labourers
  • Academic professionals

4.How to use nootropics:

It will vary depending on each type of nootropic you take, however, if you supplement with a natural nootropic following there steps, you’re more likely to feel its full-effects.

Use these steps to get the most out of your natural nootropic:

4.1 Reduce caffeine/alcohol consumption:

Over consuming caffeine and alcohol while taking nootropics may blunt its effects. Caffeine and alcohol stimulate the neuron receptors in the brain, while at the same time, releasing adrenaline into the body and disrupting normal hormone production.

If too much adrenaline is being released into the body, it impairs the uptake of other vital vitamins and minerals. Thus, removing stimulants such as caffeine and alcohol will improve the delivery of nootropics to your mind, and the rest of your body.

4.2 Eat a clean and healthy diet:

Eating a bad diet can result in weight gain, mood swings, and cravings for sugar and processed food. The more toxins you have in your body, the harder it will be for your body to process healthy nutrients, and the ingredients contained in natural nootropics.

Thus, aim to eat whole foods with as much variety as possible that’s available to you.

4.3 Quality sleep:

Poor quality sleep, over long periods of time, are directly linked to decreased memory, impaired cognitive function, and reduced ability to problem solve.

Bu making sure you get a solid 6-8 hours sleep every night in the same sleeping pattern, will help you to feel better, but also to experience more positive effects from natural nootropics.

4.4 Exercise:

Exercise not only improves overall health and longevity, it also helps to reduce toxins within the body. The less toxins that are present within the body, the more you will feel the powerful effects of nootropics.

4.5 Hydration:

As we’ve mentioned caffeine and alcohol, it’s also worth mentioning hydration. We recommend drinking water for the most part. But, if you feel the need to consume hot beverages, such as tea, we recommend only taking in small amounts of herbal, or green teas throughout the day – mainly drinking only plane water.

This will help the natural nootropic to work on its own accord to its full potential.

5.How long does it takes to work:

Many studies have reported the physical effects of some nootropics can be felt immediately 1-2 hours, or within several hours of ingesting the supplement.

However, to feel the full benefits of a natural nootropic, it’s beneficial to take the smart drug for the duration of the course; stated by the manufacturer. This is usually 1 month.

Even though taking a nootropic can be felt almost immediately, and even more so after one month. It’s reported that by supplementing with a natural nootropic for longer durations will yield the best results.

If you stick to a healthy lifestyle, and continue to supplement with a nootropic, you will most certainly feel the positive effects as long as you follow the recommended dosage.

6.How long will it last:

In simple terms, a nootropic will last as long as you take it. If you follow a healthy lifestyle, including a balanced diet, rounded sleeping pattern, and active life, then the use of a natural nootropic will continue to benefit you for as long as you use it as stated by the instructions.

7.How natural nootropics works:

A nootropic works to enhance areas of the brain that may be in decline through age, a poor diet, lifestyle, or environmental challenges. One of the main components in a nootropic is Citicoline.

Citicoline can boost brain cell membrane formation by 26% and brain energy by 13.6%. However, a trusted natural nootropic will contain at least 6 natural ingredients to boost cognitive function and prevent age related illnesses not just one single ingredient.

A nootropic works to energize, and improve mental performance, without the crash of stimulants such as caffeine. Citicoline as an example, has shown to stimulate mood balance memory, improve attention, focus and concentration.

(image courtesy of MindLabPro – showing the improvement in brain function through Citicoline)

7.1 Long Term Result

Long term results suggest it may help to maintain healthy brain function against age-related structural changes, and mental decline. Nootropics have also been suggested to help with recovery after brain injury.

Improved cognitive function is also another benefit. This could make natural nootropics highly qualified for the purpose of brain cell regeneration and repair.

Nootropics also support the strengthening of neurotransmitters, while supplying the brain with a protective antioxidant level. This means they could not only enhance the brain’s capacity to perform, but also provide detoxifying benefits at the same time.

8.Any side effects to natural nootropics?

There are no reported side effects from natural nootropics when used correctly following the recommended dosage.

However, taking ‘any’ supplement excessively outside of the suggested dosage may result in adverse effects.

With this in mind, it’s always best to read the label, and or consult your doctor before using any new supplement or medication and follow their instructions.

9.Results to expect:

As everyone’s needs are different when it comes to using a natural nootropic. As some people want to improve working capacity, while others want to think quicker, or perform better at sports- natural nootropics are there to help.

There are also those who’ll be using it to prevent cognitive decline due to age related symptoms. All of which can prevent these symptoms (or improve in some instances) by supplementing with a smart drug.

Below is a graph highlighting the results of a study conducted by a group of individuals using nootropics.

The highest point in the line graph shows the point where the participants supplemented with a high dosage of nootropics. This is where their memory increased the most.

As the participants reduced their servings of the nootropic, so did their overall capacity to remember and hold information.

This doesn’t mean to say taking more nootropics than the recommended dosage will result in a higher memory capacity. There is a total limit that one can reach while supplementing with a nootropic.

However, this goes to show how using nootropics can certainly increase memory, and working capacity.

9.1 Real-life results of natural nootropics

Many things will affect how a nootrópic work, such as our lifestyles, our diet, where we live in the world, and environmental changes. These factors will all have an impact on how you’ll use a Nootrópico to benefit your life.

However, one thing’s for sure, taking a quality natural nootropic will result in the following:

9.2 Summary of results

  • More energy and endurance
  • Improved capacity to hold information
  • Enhanced mood
  • Quicker thinking
  • Hold conversations for longer
  • Improved creativity
  • Problem solving becomes easier
  • Work for longer effortlessly

10. How to choose a natural nootropic:

When choosing a Nootrópico, it’s important to look out for a few signs from the manufacture. Such as; what ingredients are inside the natural Nootrópico and do they follow our guidelines, how reputable the company is, and if they have extensively tested their product.

Use this checklist to get the best nootropic:

  • Look for quality ingredients contained on our list
  • Buy natural nootropics only
  • Don’t buy from Amazon/eBay
  • Only buy scientifically tested products
  • Don’t buy cheap (higher price will result in the best outcome)
  • Buy direct from the company

10.1 Summary for choosing a natural nootropic:

Trusted brands have tested their product in a laboratory. They sell their products ONLY on their website and not from Amazon or eBay. They do this to avoid cheap imitations and counterfeit productions.

As health is the no 1 goal here, it’s worth bearing in mind the lack of security related to purchasing nootropics from these large online stores, such as Amazon and eBay. Where many people have reported encounters with fake goods.

Now that we’ve looked through the checklist for using a nootropic, here’s our ‘hand-picked’ natural nootropic that will prime and stimulate your mind – and your life!